Research progress in design of the organic fluorescence probes and its application for the detection of tumor biomarker

doi:10.3969/j.issn.1000-1565.2021.05.010

Abstract

Abstract: Fluorescence imaging with high spatial-temporal resolution and high sensitivity provides a powerful tool for visualizing dynamic biological processes. Recently, fluorescence imaging is widely used in molecular biology, cellular immunology, microbiology and oncology. Organic fluorescent probes have high safety, good biocompatibility and strong optical stability. At present, a series of organic fluorescent probes have been developed, including polydopamine nanoparticles, organic small molecule dyes, near-infrared- DOI:10.3969/j.issn.1000-1565.2021.05.010有机小分子荧光探针的设计及其在酶类肿瘤标志物检测中的研究进展段新瑞,孟天姣(陕西师范大学化学化工学院,陕西西安 710119)段新瑞理学博士,陕西师范大学化学化工学院教授,博士生导师.2003年毕业于河北大学化学与环境科学学院并获理学学士学位,2006 年毕业于河北大学获理学硕士学位,2010年毕业于中国科学院化学研究所并获理学博士学位,随后在美国南卡罗莱纳大学化学与生物化学学院进行博士后研究.主要从事癌干细胞成像、分离与相关核酸标志物检测方法学研究.在J Am Chem Soc、Chem Sci、Nat Protoc、Adv Mater、Anal Chem以及Acc Chem Res等国际知名学术杂志上发表论文50余篇.摘要:高时空分辨率和高灵敏度的荧光成像技术是一种新兴的活体可视化检测工具,广泛应用于分子生物学、细胞免疫学、微生物学以及肿瘤学等领域.由于有机荧光探针具有安全性高、生物相容性好、光学稳定性强等优点,目前已开发了一系列生物相容性好、具有易于修饰、调节光谱且易于被生物体代谢的有机小分子荧光探针,包括可见光区有机小分子染料以及近红外有机染料等.本文综述了近些年新型有机小分子荧光探针在2种肿瘤标志物检测中的研究进展.关键词:荧光成像;有机荧光探针;肿瘤标志物中图分类号:O157.1 文献标志码:A 文章编号:1000-1565(2021)05-0535-10Research progress in design of the organic fluorescence probes and its application for the detection of tumor biomarkerDUAN Xinrui, MENG Tianjiao(School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xian 710119,China)Abstract: Fluorescence imaging with high spatial-temporal resolution and high sensitivity provides a powerful tool for visualizing dynamic biological processes. Recently, fluorescence imaging is widely used in molecular biology, cellular immunology, microbiology and oncology. Organic fluorescent probes have high safety, good biocompatibility and strong optical stability. At present, a series of organic fluorescent probes have been developed, including polydopamine nanoparticles, organic small molecule dyes, near-infrared- 收稿日期:2021-05-10 基金项目:中央高校基本科研业务费项目重点项目(GK202002013) 第一作者:段新瑞(1981—),男,河北邯郸人,陕西师范大学教授、博士生导师,主要从事癌干细胞成像、分离与相关核酸标志物检测方法学研究.E-mail:duanxr@snnu.edu.cn第5期段新瑞等:有机小分子荧光探针的设计及其在酶类肿瘤标志物检测中的研究进展organic dyes, conjugated polymers and their nanoparticles. This paper reviews the recent research progress of organic small fluorescence probes in the detection of two tumor biomarkers.

Key words: fluorescence imaging, organic fluorescence probes, tumor biomarkers

CLC Number:

O157.1

DUAN Xinrui, MENG Tianjiao. Research progress in design of the organic fluorescence probes and its application for the detection of tumor biomarker[J]. Journal of Hebei University(Natural Science Edition), 2021, 41(5): 535-544.

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