Journal of Hebei University(Natural Science Edition) ›› 2025, Vol. 45 ›› Issue (4): 372-377.DOI: 10.3969/j.issn.1000-1565.2025.04.005

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Detection of erythritol based on inhibition of luminol-artemisinin chemiluminescence

LI Xianrui1,WANG Beibei2, SUN Yingying1, LI Jia3   

  1. 1.College of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China; 2. Experimental Center for Teaching, Hebei Medical University, Shijiazhuang 050017, China; 3. Department of Clinic, Hebei Medical University, Shijiazhuang 050017, China
  • Received:2024-10-28 Online:2025-07-25 Published:2025-07-11

Abstract: Under the catalytic action of hemin, artemisinin can oxidize luminol to produce luminescence. Erythritol has a significant inhibitory effect on the luminous intensity of the system, and the decreased value of light signal has a linear relationship with the erythritol’s concentration. Based on this principle, a new method to measure erythritol was developed. Under optimum test condition, the linear range of this method is 0.028~2.0 mg/mL(R2 =0.997 8), and the detection limit of this method is 1.6×10-2 mg/mL. The standard deviation is 3.2% after measuring 0.50 mg/mL erythritol eleven times continuously.

Key words: erythritol, Cu-hemin MOFs, chemiluminescence, inhibition

CLC Number: